Design Synthesis Biological Evaluation And Molecular Modeling Study

Synthesis And Biological Evaluation 1 5 PDF | PDF | Analysis Of ...

Synthesis And Biological Evaluation 1 5 PDF | PDF | Analysis Of ... Novel marchantin c derivatives were synthesized and evaluated as anticancer agents. derivatives showed improved anticancer activity compared to positive controls. derivatives were also effective in multidrug resistant cancer cell line. a focused structure activity relationship was discussed. A new series of imidazothiazole derivatives bearing thiazolidinone moiety (4a g and 5a d) were designed, synthesized and evaluated for potential epidermal growth factor receptor (egfr).

(PDF) Design, Synthesis, Biological Evaluation, 2D-QSAR Modeling, And ...

(PDF) Design, Synthesis, Biological Evaluation, 2D-QSAR Modeling, And ... The data that support the findings of this study are available in the supplementary material of this article. Several studies have focused on the design and synthesis of compounds containing pyrazole moiety as antioxidant, as shown in figure 1. In this study, we evaluated the in vitro anti proliferative activity of 20 compounds and the positive control drug 5 fluorouracil against mcf 7, a 549, and siha tumor cells. In this study, twenty eight new compounds based on thieno [2,3 d]pyrimidine scaffold were synthesized as anti pancreatic cancer agents mimicking the benzofuro [3,2 d]pyrimidine derivative, amuvatinib.

(PDF) Design And Synthesis Of Molecular Machines

(PDF) Design And Synthesis Of Molecular Machines In this study, we evaluated the in vitro anti proliferative activity of 20 compounds and the positive control drug 5 fluorouracil against mcf 7, a 549, and siha tumor cells. In this study, twenty eight new compounds based on thieno [2,3 d]pyrimidine scaffold were synthesized as anti pancreatic cancer agents mimicking the benzofuro [3,2 d]pyrimidine derivative, amuvatinib. In this work, new derivatives of biphenyl pyrazole‐benzofuran hybrids were designed, synthesized and evaluated in vitro through enzymatic assay for inhibitory efect against α‐glucosidase. Herein, a novel set of imidazo isoxazole derivatives containing thiourea and urea scaffolds were synthesized, characterized (1 h nmr, 13 c nmr, and elemental analysis). The main focus of her research activity concerns the following: the study of new molecules as anticancer drugs; the design, synthesis and biological evaluation of compounds of pharmaceutical interest; the study and biological evaluation of nutraceuticals. In this work, new derivatives of biphenyl pyrazole benzofuran hybrids were designed, synthesized and evaluated in vitro through enzymatic assay for inhibitory effect against α glucosidase activity.